Journal article
Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study
T Mansell, R Saffery, S Burugupalli, AL Ponsonby, MLK Tang, M O'hely, S Bekkering, AAT Smith, R Rowland, S Ranganathan, PD Sly, P Vuillermin, F Collier, P Meikle, D Burgner
Elife | Published : 2022
DOI: 10.7554/eLife.75170
Abstract
Background: The risk of adult onset cardiovascular and metabolic (cardiometabolic) disease accrues from early life. Infection is ubiquitous in infancy and induces inflammation, a key cardiometabolic risk factor, but the relationship between infection, inflammation, and metabolic profiles in early childhood remains unexplored. We investigated relationships between infection and plasma metabolomic and lipidomic profiles at age 6 and 12 months, and mediation of these associations by inflammation. Methods: Matched infection, metabolomics, and lipidomics data were generated from 555 infants in a pre-birth longitudinal cohort. Infection data from birth to 12 months were parent-reported (total infe..
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Awarded by Percy Baxter Charitable Trust
Funding Acknowledgements
The authors thank the BIS participants for the generous contribution they have made to this project. The authors also thank current and past staff for their efforts in recruiting and maintaining the cohort and in obtaining and processing the data and biospecimens. The members of the BIS Steering Committee are the following: Peter Vuillermin, Anne-Louise Ponsonby, John Carlin, Mimi LK Tang, Fiona Collier, Amy Loughman, Toby Mansell, Lawrence Gray, Martin O'Hely, Richard Saffery, Sarath Ranganathan, David Burgner, Peter Sly, and Leonard Harrison. We thank Terry Dwyer and Katie Allen for their past work as foundation investigators.